CENTER FOR NEUROSCIENCE IMAGING RESEARCH

Lab Name: Neurovascular Coupling Laboratory

Introduction

Our laboratory aims to understand the basic mechanism of physiological interaction among neurons, glias and vascular system and provide better insights for perfusion related neuroimaging techniques. Our particular research interests include: 1) Study the effect of chronic stress on neurovascular coupling at functional and structural level, 2) Study  the effect of pathologically heightened neuronal excitation and synchronization on neurovascular coupling at functional and structural level and develop cell-therapy for epilepsy, 3) Study neurovascular coupling mechanism through neurovascular coupling modulators, such as nitric oxide, carbon monoxide, & glucose, and 4) Develop novel techniques to restore neurovascular coupling dysfunction

Selected Recent Publication

1. Lee S, Kang B, Shin M, Min J, Heo C, Lee Y, Baeg E, Suh M*, "Chronic stress decreases cerebrovascular responses during rat hindlimb electrical stimulation", Frontiers in Neuroscience 23;9:462, 2015.

2. Im S, Kim WJ, Kim YH, Lee S, Koo JH, Lee JA, Kim HM, Park HJ, Kim DH, Lee HG, Yoon H, Kim JY, Shin JH, Kim LK, Doh J, Kim H, Bothwell ALM, Lee SK, Suh M, Choi JM^*, "A novel CNS-permeable peptide, dNP2 enables cytoplasmic domain of CTLA-4 protein to regulate autoimmune encephalomyelitis", Nature Communication 15;6:8244, 2015.

3. Jo A, Heo C, Schwartz TH, Suh M*, "Nanoscale intracortical iron injection induces chronic epilepsy in rodent", Journal of Neuroscience Research 92(3):389-397, 2014.

4. Heo C, Lee SY, Jo A, Jung S, Suh M*, Lee YH*, "Flexible, transparent, and non-cytotoxic graphene electric field stimulator for effective cerebral blood volume enhancement", ACS Nano 25;7(6):4869-4878, 2013.

5. Jo A, Do H, Jhon GJ, Suh M*, Lee Y*, "Electrochemical nanosensor for real-time direct imaging of nitric oxide in living brain", Anal Chem 1;83(21):8314-8319, 2011.

Neurophotonics Lab

Introduction

We use light as a tool to understand and manipulate living biological system, aiming to address pressing problems in neuroscience. Our research theme includes but is not limited to intravital imaging techniques, optical neuromodulation, and bio-integrated photonics. We take multidisciplinary approaches integrating optics, engineering, and biomedicine.

Selected Recent Publications

1. Choi M, Choi JW, Kim S, Nizamoglu S, Hahn SK, Yun SH, "Light-guiding hydrogels for cell-based sensing and optogenetic synthesis in vivo", Nature Photonics 7(12): 987-994, 2013 (featured in Nature Photonics, Nature Methods, Nature Review of Endocrinology, Thomson Reuter, etc.).

2. Choi M, Ku T, Chung K, Yoon J, Choi C, "Minimally invasive molecular delivery into the brain using optical modulation of vascular permeability", PNAS 108(22): 9256-9261, 2011.

3. Kim JK*, Lee WM*, Kim P*, Choi M*, Jung K, Kim S, Yun SH, "Fabrication and operation of GRIN probes for in vivo fluorescence cellular imaging of internal organs in small animals",  Nature Protocols 7: 1456-1469, 2012 (*co-first author; cover article).

4. Choi M, Humar M, Kim S, Yun SH, "Step-index optical fiber made of biocompatible hydrogels",  Advanced Materials 27: 4081-4086, 2015.

5. Choi M, Lee WM, Yun SH, "Intravital microscopic interrogation of peripheral taste sensation",  Scientific Reports 5: 8661, 2015.