Hyung Jin Choi, Ph.D.
October 24(Mon) - October 24(Mon), 2022
1pm
N Centre 86314 & ZOOM (ID: 728-142-6028)
CNIR Seminar
Date: 1pm, Monday, Oct 24th
과학 뇌이(가) 예약된 Zoom 회의에 귀하를 초대합니다.
https://us02web.zoom.us/j/7281426028
회의 ID: 728 142 6028 (password: cnir)
Speaker: Hyung Jin Choi, Ph.D. (Seoul National University, Collefe of Medicine)
Title: Two Distinct Lateral Hypothalamic Neurons Regulate Hunger-Gated Food-Seeking and Consummatory Behaviours
Abstract: The physiological need for energy evokes motivated feeding behaviours that help to ensure survival. However, the neural mechanisms underlying the generation of food motivation remain poorly understood. We investigated these mechanisms by subdividing feeding-related motivated behaviours into food-seeking and consummatory behaviours. Micro-endoscopic results indicated that neurons containing leptin receptors (LepRs) in the lateral hypothalamus (LH) are the major food-specific subpopulation of LHGABA neurons. Optogenetic manipulation of LHLepR neurons bidirectionally regulated both food-seeking and consummatory behaviours. Furthermore, micro-endoscope data revealed that distinct LHLepR neurons encode seeking and consummatory behaviours. Computational modeling analysis demonstrated that LHLepR neurons encode motivation, whereas neurons containing agouti-related peptide and neuropeptide Y (AgRP/NPY) encode the need for food. Additionally, slice studies revealed that NPY decreases inhibitory input to LHLepR neurons via LHGABA interneurons. This mechanism explains the permissive gate role of hunger (food need) in seeking/consummatory motivation. Together, the present study provides a comprehensive neural mechanism of how physiological needs drive two distinct motivated behaviours.