Jiyoung Kang, Ph.D.
October 14(Thu) - October 14(Thu), 2021
12PM
ZOOM (ID: 728-142-6028)
Neuro@noon Seminar
Date: 12PM, Thursday, October 14th
ZOOM 회의 참가 ID: 728-142-6028
Speaker: Jiyoung Kang, Ph.D.
(Department of Scientific Computing, Pukyong National Univ.)
Title: Toward mechanism-based brain treatments: theoretical and computational approaches
Abstract:
The purpose of treatment for brain disease is to achieve desirable brain function via the modification of brain circuitry. Recent developments in computational methods have been geared towards optimal brain treatment. However, in most previous computational studies, the brain’s self-restoration process after the treatment has not been fully considered, and the brain may not reach its optimal state. In the present talk, we propose a computational scheme for optimal brain treatment considering both the nonlinear dynamical brain and its self-restorative process. Specifically, we adopted two principles, free energy and degeneracy of the brain, to formulate a computational model of the self-restoration process. Constructing a brain system with the resting-state fMRI data from the Human connectome project, we tested the current framework and conducted various simulations. Our computational framework showed that treatment without consideration of the self-restoration process could be less optimal, and that optimizing the strength and timing of repetitive treatments could be a useful method of finding better options for treatment, which suggests the proposed computational framework can be a useful tool for searching for optimal controls of the dynamic brain after treatment.