논문명 |
The effect of intensive statin therapy in non-symptomatic intracranial arteries: The STAMINA-MRI sub-study |
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저자 |
Jae Eun Sim, Ha-Na Song, Jong-Un Choi, Ji-Eun Lee, In Young Baek, Hwan-Ho Cho, Jong-Hoon Kim, Jong-Won Chung, Gyeong-Moon Kim, Hyun-Jin Park, Oh Young Bang and Woo-Keun Seo |
저널 |
Frontiers in Neurology 14, 1069502-(2023) |
Abstract |
www.frontiersin.org/articles/10.3389/fneur.2023.1069502/full |
This is a sub-study of a prospective observational study under the title of “Intensive Statin Treatment in Acute Ischemic Stroke Patients with Intracranial Atherosclerosis: a High-Resolution Magnetic Resonance Imaging (HR-MRI) study.” Patients with statin-naive acute ischemic stroke who had symptomatic intracranial artery stenosis (above 50%) were recruited for this study. HR-MRI was performed to assess the patients’ cerebral arterial status before and 6 months after the statin therapy. To demonstrate the effect of statins in the non-symptomatic segment of intracranial cerebral arteries, we excluded symptomatic segments from the data to be analyzed. We compared the morphological changes using cerebrovascular morphometry. A total of 54 patients (mean age: 62.9 ± 14.4 years, 59.3% women) were included in this study. Intensive statin therapy produced significant morphological changes of overall cerebral arteries. Among the morphological features, the arterial luminal area showed the highest number of significant changes with a range from 5.7 and 6.7%. Systolic blood pressure (SBP) was an independent factor associated with relative changes in posterior circulation bed maximal diameter percentage change (beta −0.21, 95% confidence interval −0.36 to −0.07, p = 0.005). |